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Search results 7701 to 7800 out of 30763 for seed protein

Category restricted to ProteinDomain (x)

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0.034s

Categories

Category: ProteinDomain
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Type Details Score
Protein Domain
IPR007015
Name: DNA polymerase V/Myb-binding protein 1A
Type: Family
Description: Proteins of this family are predominantly nucleolar. Myb-binding protein 1A (MYBBP1A) is a transcription regulator that may play an important role in the cellular stress response [ , , , ]. This family also includes the fifth essential DNA polymerase (Pol5p) of Schizosaccharomyces pombe (Fission yeast) and Saccharomyces cerevisiae (Baker's yeast) (). Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units [ ]. This protein was originally thought to be a DNA polymerase, however, later reseach indicated its involvement in ribosome assembly [, ].
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Protein Domain
IPR020606
Name: Ribosomal protein S7, conserved site
Type: Conserved_site
Description: Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [ , ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [ , ].Ribosomal protein S7 is one of the proteins from the small ribosomal subunit. In Escherichia coli, S7 is known to bind directly to part of the 3'end of 16Sribosomal RNA. It belongs to a family of ribosomal proteins which have been grouped on the basis of sequence similarities [ , ].This entry represents a conserved site located in the N-terminal section of the proteins.
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Protein Domain
IPR013714
Name: Golgi apparatus membrane protein TVP15
Type: Family
Description: Proteins in this family co-localise with COPI vesicle coat proteins [ ]. In yeast it is a Golgi membrane protein involved in vesicular trafficking, interacting with Tvp18 and Tvp23 [, ].
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Protein Domain
IPR018710
Name: Protein of unknown function DUF2232
Type: Family
Description: This family of bacterial and eukaryotic proteins has no known fucntion.
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Protein Domain
IPR018279
Name: Ribosomal protein S21e, conserved site
Type: Conserved_site
Description: Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [ , ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [ , ].A number of eukaryotic ribosomal proteins can be grouped on the basis of sequence similarities. These proteins have 82 to 87 amino acids. The amino termini are all N alpha-acetylated. The N-terminal halves of the protein molecules are highly conserved in contrast to the carboxy-terminal parts [].
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Protein Domain
IPR025889
Name: General stress protein 17M-like domain
Type: Domain
Description: This domain is found in stress induced proteins, mainly from Bacilli. General stress protein 17M or YflT is induced by heat shock, salt stress, oxidative stress, glucose limitation and oxygen limitation [ ]. This domain is also found at the N terminus of stress response protein YsnF, induced by phosphate starvation, via the alternative sigma factor sigma-B [].
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Protein Domain
IPR013893
Name: Ribonuclease P protein subunit Rpp40
Type: Family
Description: Ribonuclease P (Rnp) is a ubiquitous ribozyme that catalyzes a Mg2 -dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) in all three domains of life [ ]. In bacteria, the catalytic RNA (typically ~120kDa) is aided by a small protein cofactor (~14kDa) []. Archaeal and eukaryote RNase P consist of a single RNA and archaeal RNase P has four or five proteins, while eukaryotic RNase P consists of 9 or 10 proteins. Eukaryotic and archaeal RNase P RNAs cooperatively function with protein subunits in catalysis [].This entry represents Rpp40 from eukaryotes. Human RNase P is composed of a singular protein Pop1 and three subcomplexes, the Rpp20-Rpp25 heterodimer, Pop5-Rpp14-(Rpp30)2-Rpp40 heteropentamer, and Rpp21-Rpp29-Rpp38 heterotrimer [ ].
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Protein Domain
IPR013897
Name: Protein of unknown function DUF1769
Type: Family
Description: This entry is found in fungal proteins with unknown function.
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Protein Domain
IPR013895
Name: Chromatin structure-remodeling complex protein Rsc14
Type: Family
Description: RSC is an ATP-dependent chromatin remodelling complex found in yeast. The RSC components Rsc7/Npl6 and Rsc14/Ldb7 interact physically and/or functionally with Rsc3, Rsc30, and Htl1 to form a module important for a broad range of RSC functions [ ].
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Protein Domain
IPR035262
Name: Protein of unknown function DUF5435
Type: Family
Description: This is a family of unknown function found in Varicellovirus.
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Protein Domain
IPR035264
Name: Protein of unknown function DUF5434
Type: Family
Description: This is a family of unknown function found in Varicellovirus.
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Protein Domain
IPR047237
Name: DCC-interacting protein 13-alpha/beta, PTB domain
Type: Domain
Description: This entry represents the PTB domain of DPA13A/B. PTB domains have a common PH-like fold and are found in various eukaryotic signalling molecules.This entry includes DCC-interacting protein 13-alpha/beta from humans (DIP13A/B, also known as APPL1/2) and similar proteins predominantly found in vertebrates. DIP13A/B are multifunctional adapter proteins that bind to various membrane receptors, nuclear factors and signalling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism [ , , , , ]. DIP13B may also affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor [, ]. These proteins consist of a BAR and a PH domain near the N-terminal, and the two domains are thought to function as a unit (BAR-PH domain) [ ]. At the C-terminal, they have a PTB domain []. Lipid binding assays show that the BAR, PH, and PTB domains can bind phospholipids [].
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Protein Domain
IPR035257
Name: Protein of unknown function DUF5349
Type: Family
Description: This is a family of unknown function found in Saccharomycetaceae.
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Protein Domain
IPR035258
Name: Protein of unknown function DUF5350
Type: Family
Description: This family is found in Euryarchaeota, predominantly in Methanomicrobia and Archaeoglobi. No known function for this family has been demonstrated.
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Protein Domain
IPR035259
Name: Protein of unknown function DUF5437
Type: Family
Description: This is a family of unknown function found in Alphabaculovirus.
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Protein Domain
IPR035249
Name: Protein of unknown function DUF5441
Type: Family
Description: This is a family of unknown function found in Mastadenoviruses.
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Protein Domain
IPR035241
Name: Protein of unknown function DUF5442
Type: Family
Description: Proteins in this family are found in the midge Chironomus thummi. They are encoded by genes contained in Balbiani ring A, a large puff (active region) on the polytene chromosomes of Chironomus [ ].
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Protein Domain
IPR035242
Name: Protein of unknown function DUF5329
Type: Family
Description: This is a bacterial family of proteins with unknown function, mostly found in Proteobacteria.
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Protein Domain
IPR035238
Name: Protein of unknown function DUF5345
Type: Family
Description: This is a family of unknown function. It is found mostly in Bacteria. Members of this family are predicted to contain two trans-membrane regions.
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Protein Domain
IPR035231
Name: Protein of unknown function DUF5346
Type: Family
Description: This family of unknown function is found in Nematoda.
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Protein Domain
IPR035232
Name: Protein of unknown function DUF5347
Type: Family
Description: This family of unknown function is found mainly in Proteobacteria.
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Protein Domain
IPR035233
Name: Protein of unknown function DUF5443
Type: Family
Description: This is a family of unknown function found in Mycoplasma.
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Protein Domain
IPR035235
Name: Protein of unknown function DUF5343
Type: Family
Description: This is a family of unknown function mostly found in Bacteria.
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Protein Domain
IPR035237
Name: Protein of unknown function DUF5341
Type: Family
Description: This is a family of unknown function, which can be found mostly in Ascomycota.
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Protein Domain
IPR035291
Name: Protein of unknown function DUF5354
Type: Family
Description: This family of unknown function is found mostly in nematodes.
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Protein Domain
IPR035292
Name: Protein of unknown function DUF5363
Type: Family
Description: This is a family of unknown function found in Gammaproteobacteri.
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Protein Domain
IPR035281
Name: Protein of unknown function DUF5359
Type: Family
Description: This is a family of unknown function found in Bacillales. Most of the family members are predicted to have one trans-membrane region.
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Protein Domain
IPR035282
Name: Protein of unknown function DUF5429
Type: Family
Description: This is a family of unknown function found in Human cytomegalovirus.
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Protein Domain
IPR035284
Name: Protein of unknown function DUF5428
Type: Family
Description: This is a family of unknown function found in Betanecrovirus.
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Protein Domain
IPR035286
Name: Protein of unknown function DUF5361
Type: Family
Description: This is a family of unknown function found in bacteria and virus.
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Protein Domain
IPR035287
Name: Protein of unknown function DUF5362
Type: Family
Description: This is a family of unknown function found in Bacteria. Most of the family members are predicted to have 2 trans-membrane regions.
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Protein Domain
IPR035289
Name: Protein of unknown function DUF5366
Type: Family
Description: This is a family of unknown function, found in Bacillales. Members of the family are predicted to have between 4 and 5 trans-membrane regions.
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Protein Domain
IPR035270
Name: Protein of unknown function DUF5433
Type: Family
Description: This is a family of unknown function found in Orthopoxviruses.
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Protein Domain
IPR035271
Name: Protein of unknown function DUF5432
Type: Family
Description: This is a family of unknown function found in Orthopoxvirus.
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Protein Domain
IPR035272
Name: Protein of unknown function DUF5351
Type: Family
Description: This family of unknown function is found in Bacillales.
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Protein Domain
IPR035273
Name: Protein of unknown function DUF5431
Type: Family
Description: This is a family of unknown function found in Enterobacteriaceae.
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Protein Domain
IPR035274
Name: Protein of unknown function DUF5352
Type: Family
Description: This is a family of unknown function found mostly in Nematoda.
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Protein Domain
IPR035275
Name: Small integral membrane protein 3
Type: Family
Description: Smim3 (Small integral membrane protein 3) also known as NID67 (NGF-induced differentiation clone 67) may be involved in forming or regulating ion channels in neuronal differentiation. It is strongly induced by NGF (Nerve Growth Factor) and FGF (Fibroblast Growth Factor), both of which cause these cells to differentiate. The amino acid sequence of NID67 is strongly conserved among rat, mouse and human. This family of small membrane proteins is only 60 amino acids long and analysis of the predicted peptide sequence reveals a stretch of 29 hydrophobic and uncharged residues which very likely comprise a trans-membrane region [ ].
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Protein Domain
IPR035276
Name: Feline immunodeficiency virus OrfA protein
Type: Family
Description: OrfA protein is a multifunctional accessory protein found in Feline immunodeficiency virus (FIV), a lentivirus that causes AIDS in domestic cats [ ]. Multiple potential functions have been ascribed to OrfA, including transactivation of viral protein expression [], effects on virion formation and infectivity [], host cell cycle arrest [] and downregulation of cell surface expression of the primary FIV receptor, CD134 []. This protein can also be found in Puma lentivirus.
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Protein Domain
IPR035278
Name: Protein of unknown function DUF5355
Type: Family
Description: This family of unknown function is found in Saccharomycetales.
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Protein Domain
IPR035279
Name: Protein of unknown function DUF5358
Type: Family
Description: This family of unknown function is found in Proteobacteria.
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Protein Domain
IPR013712
Name: Mitochondrial Myo2 receptor-related protein 1
Type: Family
Description: Myo2p, a class V myosin, is essential for mitochondrial distribution, class V being vital for organelle distribution in S. cerevisiae. The established mechanism for distribution of cellular components by class V myosins is that they interact with the cargo at the C-terminal tail domain and transport it along the actin cytoskeleton using the N-terminal motor domain. Cargo-specific myosin receptors act as the link between the myosin tail and cargo. Myo2 binds with MMR1 (mitochondrial Myo2p receptor-related protein 1), the receptor on cargo, via the C-terminal domain [ ].
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Protein Domain
IPR001738
Name: Rab protein geranylgeranyltransferase component A
Type: Family
Description: Rab proteins constitute a family of small GTPases that serve a regulatory role in vesicular membrane traffic [ , ]; C-terminal geranylgeranylation is crucial for their membrane association and function. This post-translational modification is catalysed by Rab geranylgeranyl transferase (Rab-GGTase), a multi-subunit enzyme that contains a catalytic heterodimer and an accessory component, termed Rab escort protein (REP)-1 [, ]. REP-1 presents newly-synthesised Rab proteins to the catalytic component, and forms a stable complex with the prenylated proteins following the transfer reaction.cDNA cloning of component A of rat Rab geranylgeranyl transferase (REP) confirms its resemblance to Rab3A guanine nucleotide dissociation inhibitor (GDI) and its identity with the human choroideremia gene product []. A genetic defect in REP underlies human choroideremia. Choroideraemia (or tapetochoroidal dystrophy) is a common form of X-linked blindness characterised by progressive dystrophy of the choroid, retinal pigment epithelium and retina [, , ].
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Protein Domain
IPR001742
Name: Outer capsid protein VP2, Orbivirus
Type: Family
Description: This family contains the outer capsid, VP2 proteins from the orbiviruses; these are dsRNA viruses belonging to the Reoviridae. VP2 acts as an anchor for VP1 and VP3 and contains a non-specific DNA and RNA binding domain in the N terminus [ , ].
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Protein Domain
IPR006302
Name: Type III secretion protein HrcV
Type: Family
Description: Members of this family are closely homologous to the flagellar biosynthesis protein FlhA and should all participate in type III secretion systems. Examples include InvA (Salmonella enterica), LcrD (Yersinia enterocolitica), HrcV (Xanthomonas), etc. Type III secretion systems resemble flagellar biogenesis systems, and may share the property of translocating special classes of peptides through the membrane.
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Protein Domain
IPR011101
Name: Protein of unknown function DUF5131
Type: Family
Description: This is a family of bacterial and phage proteins of unknown function. There are three highly conserved cysteine residues in the disposition Cx6Cxxc, amongst many highly conserved residues.
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Protein Domain
IPR025713
Name: Motility protein B-like, N-terminal domain
Type: Domain
Description: This domain is found in MotB, a component of the Escherichia coli MotA/MotB proton-channel complex that forms the stator of the bacterial membrane flagellar motor. Key residues in MotB act as a plug to prevent premature proton flow. The plug is in the periplasm just C-terminal to the MotB TM (transmembrane helix), consisting of an amphipathic α-helix flanked by Pro-52 and Pro-65, eg in . In addition to the Pro residues, Ile-58, Tyr-61, and Phe 62 are also essential for plug function [ , ].This domain is also found in ZorB, a distant homologue of MotB. ZorB is a component of the antiviral defense system Zorya type I, composed of ZorA, ZorB, ZorC and ZorD. ZorA and ZorB may assemble in the cell inner membrane [ ].
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Protein Domain
IPR013799
Name: STAT transcription factor, protein interaction
Type: Domain
Description: The STAT protein (Signal Transducers and Activators of Transcription) family contains transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors, hence they act as signal transducers in the cytoplasm and transcription activators in the nucleus [ ]. Binding of these factors to cell-surface receptors leads to receptor autophosphorylation at a tyrosine, the phosphotyrosine being recognised by the STAT SH2 domain, which mediates the recruitment of STAT proteins from the cytosol and their association with the activated receptor. The STAT proteins are then activated by phosphorylation via members of the JAK family of protein kinases, causing them to dimerise and translocated to the nucleus, where they bind to specific promoter sequences in target genes. In mammals, STATs comprise a family of seven structurally and functionally related proteins: Stat1, Stat2, Stat3, Stat4, Stat5a and Stat5b, Stat6. STAT proteins play a critical role in regulating innate and acquired host immune responses. Dysregulation of at least two STAT signalling cascades (i.e. Stat3 and Stat5) is associated with cellular transformation.Signalling through the JAK/STAT pathway is initiated when a cytokine binds to its corresponding receptor. This leads to conformational changes in the cytoplasmic portion of the receptor, initiating activation of receptor associated members of the JAK family of kinases. The JAKs, in turn, mediate phosphorylation at the specific receptor tyrosine residues, which then serve as docking sites for STATs and other signalling molecules. Once recruited to the receptor, STATs also become phosphorylated by JAKs, on a single tyrosine residue. Activated STATs dissociate from the receptor, dimerise, translocate to the nucleus and bind to members of the GAS (gamma activated site) family of enhancers.The seven STAT proteins identified in mammals range in size from 750 and 850 amino acids. The chromosomal distribution of these STATs, as well as the identification of STATs in more primitive eukaryotes, suggest that this family arose from a single primordial gene. STATs share 6 structurally and functionally conserved domains including: an N-terminal domain (ND) that strengthens interactions between STAT dimers on adjacent DNA-binding sites; a coiled-coil STAT domain (CCD) that is implicated in protein-protein interactions; a DNA-binding domain (DBD) with an immunoglobulin-like fold similar to p53 tumour suppressor protein; an EF-hand-like linker domain connecting the DNA-binding and SH2 domains; an SH2 domain () that acts as a phosphorylation-dependent switch to control receptor recognition and DNA-binding; and a C-terminal transactivation domain [ , , ]. The crystal structure of the N terminus of Stat4 reveals a dimer. The interface of this dimer is formed by a ring-shaped element consisting of five short helices. Several studies suggest that this N-terminal dimerisation promotes cooperativity of binding to tandem GAS elements and with the transcriptional coactivator CBP/p300.This entry represents the N-terminal domain, which is responsible for protein interactions. This domain has a multi-helical structure that can be subdivided into two structural sub-domains.
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Protein Domain
IPR025786
Name: Mononegavirus L protein 2-O-ribose methyltransferase
Type: Domain
Description: Large structural protein L or protein L from Mononegavirales is responsible for the replication and transcription of the viral genome as well as all posttranscriptional modifications of viral mRNAs [ ]. The template is composed of the viral RNA tightly encapsulated by the nucleoprotein (N). The protein can function either as transcriptase or as replicase. The transcriptase synthesises subsequently subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognising the transcriptional signals [].The large structural protein carries three enzymatic activities: RNA-directed RNA polymerase ( ), mRNA (guanine-N(7)-)-methyltransferase ( ), and mRNA guanylyltransferase ( ). This entry represents the methyltransferase domain.
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Protein Domain
IPR037766
Name: Protein FAR-RED ELONGATED HYPOCOTYL 1
Type: Family
Description: This entry represents a group of plant proteins, including FHY1 (At2g37678) from Arabidopsis. Phytochrome A (phyA) is the photoreceptor in Arabidopsis that mediates the far-red light high radiance response. AtFHY1 is a key regulator of far red/red (FR/R) spectrum-specific responses by regulating phyA shuttling from the cytoplasm to the nucleus and by directly regulating the expression of some target genes. AtFHY1 phosphorylation is induced by the R signal, is part of the FR/R spectrum sensing mechanism that ensures its optimal response to specific light quality [ ]. AtFHY1 also has an independent role in gene modulation and plant development under far-red light [].This entry also includes FHL (FHY1 Like). FHL is essential for light-regulated PHYA nuclear accumulation and subsequent PHYA phototropic signaling processes [ , , ]. The transcription of FHY1 and FHL are controlled by FHY3 (Far-red elongated HYpocotyl 3) and FAR1 (FAr-red impaired Response 1), a related pair of transcription factors [].
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Protein Domain
IPR035141
Name: Protein of unknown function DUF5484
Type: Family
Description: This family of unknown function is mainly found in Myoviridae.
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Protein Domain
IPR035143
Name: Protein of unknown function DUF5483
Type: Family
Description: This is a family of unknown function found in Saccharomycetales.
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Protein Domain
IPR035145
Name: Protein of unknown function DUF5482
Type: Family
Description: This is a family of unknown function mainly found in Saccharomycetales.
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Protein Domain
IPR035146
Name: Protein of unknown function DUF5481
Type: Family
Description: This is a family of unknown function found in Myoviridae.
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Protein Domain
IPR035148
Name: Protein of unknown function DUF5480
Type: Family
Description: This is a family of unknown function found in Podoviridae.
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Protein Domain
IPR035149
Name: Protein of unknown function DUF5479
Type: Family
Description: This is a family of unknown function found in Kappa-papillomavirus.
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Protein Domain
IPR047117
Name: Proline-rich receptor-like protein kinase PERK1-13-like
Type: Family
Description: This entry represents a family of plant proteins that includes Proline-rich receptor-like protein kinase PERK1-13 from Arabidopsis thaliana. Most members of this family show a protein kinase domain.
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Protein Domain
IPR035131
Name: Protein of unknown function DUF5502
Type: Family
Description: This is a family of unknown function found in Listeria.
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Protein Domain
IPR035132
Name: Protein of unknown function DUF5501
Type: Family
Description: This is a family of unknown function found in Alphabaculovirus.
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Protein Domain
IPR035133
Name: Protein of unknown function DUF5499
Type: Family
Description: This is a family of unknown function found in Myoviridae.
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Protein Domain
IPR035134
Name: Protein of unknown function DUF5498
Type: Family
Description: This is a family of unknown function found in Myoviridae.
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Protein Domain
IPR035135
Name: Protein of unknown function DUF5496
Type: Family
Description: This is a family of unknown function found in Myoviridae.
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Protein Domain
IPR035136
Name: Protein of unknown function DUF5486
Type: Family
Description: This is a family of unknown function found in Myoviridae.
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Protein Domain
IPR035138
Name: Protein of unknown function DUF5485
Type: Family
Description: This is a family of unknown function found in Alphabaculovirus.
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Protein Domain
IPR035120
Name: Protein of unknown function DUF5509
Type: Family
Description: This is a family of unknown function found in Baculoviridae.
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Protein Domain
IPR035123
Name: Viral unique long protein 16
Type: Family
Description: This family contains members such as UL16 found in the human cytomegalovirus (HCMV). It is an immunoevasin which subverts NKG2D-mediated immune responses by retaining a select group of diverse NKG2D ligands inside the cell. UL16 is a heavily glycosylated 50kDa type I trans-membrane glycoprotein. The ectodomain folds into a modified version of the a variable (V-type) (immunoglobulin Ig)-like domain. The N-terminal 'plug' region (amino acids 27-50) is covalently linked to the Ig-like core with a disulfide bond. UL16 protein utilizes a three-stranded β-sheet to engage the α-helical surface of the MHC class I-like MICB platform domain. Residues at the centre of this β-sheet mimic a central binding motif employed by the structurally unrelated C-type lectin-like NKG2D to facilitate engagement of diverse NKG2D ligands [ ].
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Protein Domain
IPR035124
Name: Protein of unknown function DUF5508
Type: Family
Description: This is a family of unknown function found in Enterobacteriaceae. It includes uncharacterized protein YpjB.
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Protein Domain
IPR037789
Name: Rab11-family interacting protein class I
Type: Family
Description: Rab GTPases recruit various effector proteins to organelles and vesicles. Rab11-family interacting proteins (FIPs) are involved in mediating the role of Rab11. FIPs can be divided into three classes: class I FIPs (Rip11/Rab11-FIP5, RCP/RAB11FIP1, and FIP2) which contain a C2 domain after N terminus of the protein, class II FIPs (FIP3 and FIP4) which contain two EF-hands and a proline rich region, and class III FIPs (FIP1) which exhibits no homology to known protein domains. All FIP proteins contain a highly conserved, 20-amino acid motif at the C terminus of the protein, known as Rab11/25 binding domain (RBD). Class I FIPs are thought to bind to endocytic membranes via their C2 domain, which interacts directly with phospholipids. Class II FIPs do not have any membrane binding domains leaving much to speculate about the mechanism involving FIP3 and FIP4 interactions with endocytic membranes [ ]. Class I FIPs, but not the class II FIPs, also interact with Rab14 [].The exact function of the Rab11 and FIP interaction is unknown, but there is speculation that it involves the role of forming a targeting complex that recruits a group of proteins involved in membrane transport to organelles. Recent studies have identified several Rab11-FIP complex-binding proteins that regulate distinct membrane traffic pathways [ ].This family consist of class I FIPs.
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Protein Domain
IPR035111
Name: Protein of unknown function DUF5516
Type: Family
Description: This is a family of unknown function found mostly in T7 viruses.
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Protein Domain
IPR035112
Name: Viral unique long protein 21a
Type: Family
Description: Members of this family include UL21a, found in Human cytomegalovirus (HCMV). UL21a is required for HCMV to establish efficient productive infection. It is a short-lived cytoplasmic protein that facilitates HCMV replication [ ]. It has also been shown to be responsible for APC1, APC4 and APC5 degradation [].
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Protein Domain
IPR035115
Name: Protein of unknown function DUF5514
Type: Family
Description: This is a family of unknown function found in Bacillus.
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Protein Domain
IPR035116
Name: Protein of unknown function DUF5510
Type: Family
Description: This is a family of unknown function found in Rickettsia. Family members are predicted to have 2 or 3 trans-membrane regions.
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Protein Domain
IPR035180
Name: Protein of unknown function DUF5464
Type: Family
Description: This is a family of unknown function found in Bacteriophages.
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Protein Domain
IPR035181
Name: Protein of unknown function DUF5463
Type: Family
Description: This is a family of unknown function found in Yersinia.
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Protein Domain
IPR047169
Name: Insulin gene enhancer protein ISL-1/2-like
Type: Family
Description: This group of proteins includes the DNA-binding transcriptional activators insulin gene enhancer proteins ISL-1/2 (also known as Islet-1/2) and its homologues from animals [ , ]. ISL1 recognises and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes [, , ]. The early expression of ISL-1 in the developing hypothalamus determines the fate specification of melanocortinergic neurons and is essential for hypothalamic Pomc expression. It is required for melanocortin-induced satiety and normal adiposity throughout the entire lifespan []. ISL2 is a transcriptional factor that may define subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.
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Protein Domain
IPR035182
Name: Protein of unknown function PsaF
Type: Family
Description: This is a family of unknown function mainly found in Yersinia.
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Protein Domain
IPR035183
Name: Protein of unknown function DUF5304
Type: Family
Description: This family of unknown function is found in Actinobacteria.
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Protein Domain
IPR035185
Name: Protein of unknown function DUF5305
Type: Family
Description: This family consists of several hypothetical proteins of unknown function.
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Protein Domain
IPR035186
Name: Protein of unknown function DUF5308
Type: Family
Description: This family of uncharacterised fungal proteins are primarily found in ascomycota.
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Protein Domain
IPR035187
Name: Mitochondrial peculiar membrane protein 1
Type: Family
Description: This family contains mitochondrial peculiar membrane proteins, found predominantly in Saccharomycetales. Proteins in this entry include Mpm1 from S. cerevisiae [].
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Protein Domain
IPR047163
Name: Apoptosis-stimulating of p53 protein 1/2
Type: Family
Description: Apoptosis-stimulating of p53 protein 1 (ASPP1/2) which are specific activators of p53. These proteins play a central role in regulation of apoptosis via its interaction with p53/TP53 [ , ]. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. ASPP2 inhibits the ability of APP-BP1 (also known as NEDD8 activating enzyme E1 subunit 1, NAE1) to conjugate NEDD8 to CUL1, and thereby decreases APP-BP1 ability to induce apoptosis []. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 []. ASPP1 homologue from C. elegans, apoptotic enhancer 1 protein (aep-1), negatively regulates apoptosis via its interaction with cep-1.
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Protein Domain
IPR035170
Name: Metastasis-associated protein MTA1, R1 domain
Type: Domain
Description: The R1 domain is found in the MTA1 protein and its homologues. The domain is composed of 4 alpha helices. It has been shown to bind to the RBBP4 protein [ ]. The MTA proteins contain a second partial copy of this domain called R2. The R2 domain is matched by this model for some proteins.
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Protein Domain
IPR035172
Name: Protein of unknown function DUF5302
Type: Family
Description: This is a family of unknown function found in Actinobacteria with highly conserved motif of FRRKSG found at the C terminus.
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Protein Domain
IPR047151
Name: Zinc phosphodiesterase ELAC protein 2-like
Type: Family
Description: This family represents a group of zinc phosphodiesterases including zinc phosphodiesterase ELAC protein 2 (RNZ2/ELAC2, also known as ElaC homologue protein 2 and tRNase Z 2) from human and its homologues. RNZ2 has mitochondrial tRNA 3'-processing endonuclease activity. It is involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA, playing an essential role in the production of mature tRNAs [ , , ]. The homologue from Drosophila has some tRNA 3'-processing endonuclease activity of nuclear and mitochondrial pre-tRNA. It may participate in tRNA processing in the developing embryo []. Mutations in this protein have been associated with severe form of infantile cardiomyopathy [] and and prostate cancer []. The homologue from C. elegans HOE-1 has been shown to compromise fertility [, ].
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Protein Domain
IPR035178
Name: Protein of unknown function DUF5466
Type: Family
Description: This is a family of unknown function mainly found in Enterobacteria phage T7.
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Protein Domain
IPR035179
Name: Protein of unknown function DUF5314
Type: Family
Description: This is a family of unknown function usually preceded by the GAG-pre-integrase domain ( ).
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Protein Domain
IPR035160
Name: Protein of unknown function DUF5334
Type: Family
Description: This is a family of unknown function found mainly in Proteobacteria.
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Protein Domain
IPR035161
Name: Protein of unknown function DUF5332
Type: Family
Description: This family of proteins is mostly found in Chromadorea. Proteins in this family include dct-5. Dct-5 is a target of DAF-16, a forkhead transcription factor, which is a key regulator of longevity, metabolism and dauer diapause in Caenorhabditis elegans [ ].
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Protein Domain
IPR011191
Name: Uncharacterised protein family Treponema vWA
Type: Family
Description: Members of this group are related to the 76kDa protein of unknown function from Treponema. The proteins contain a vWA domain.
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Protein Domain
IPR035162
Name: Protein of unknown function DUF5470
Type: Family
Description: This is a family of unknown function found in viruses.
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Protein Domain
IPR035165
Name: Protein of unknown function DUF5319
Type: Family
Description: This is a family of unknown function mostly found in Actinobacteria.
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Protein Domain
IPR035166
Name: Protein of unknown function DUF5336
Type: Family
Description: This Actinobacterial family of proteins has no known function. Most of the family members are predicted to have have 4 trans-membrane regions.
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Protein Domain
IPR035167
Name: Protein of unknown function DUF5316
Type: Family
Description: This is a family of unknown function mainly found in Firmicutes. It might contain multiple trans-membrane sequences.
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Protein Domain
IPR035168
Name: Protein of unknown function DUF5317
Type: Family
Description: This is a family of unknown function found mainly in Bacteria. Members of this family have multiple trans-membrane domains with the majority typically constituted of 4 trans-membrane regions.
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Protein Domain
IPR035169
Name: Protein of unknown function DUF5318
Type: Family
Description: This family of unknown function is mostly found in Actinobacteria.
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Protein Domain
IPR035153
Name: Protein of unknown function DUF5473
Type: Family
Description: This is a family of unknown function found mainly in Human mastadenovirus.
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Protein Domain
IPR035154
Name: Protein of unknown function DUF5472
Type: Family
Description: This is a family of unknown function found in Human papillomavirus.
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Protein Domain
IPR035155
Name: Protein of unknown function DUF5393
Type: Family
Description: This is a family of unknown function found in Trypanosomatidae.
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Protein Domain
IPR035156
Name: Protein of unknown function DUF5471
Type: Family
Description: This is a family of unknown function found in Enterobacteria phage T7.
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Protein Domain
IPR035157
Name: Protein of unknown function DUF5395
Type: Family
Description: This is a family of unknown function found in Archaea and Bacteria.
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