Search our database by keyword

- or -

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, pathways, authors, ontology terms, etc. (e.g. eve, embryo, zen, allele)
  • Use OR to search for either of two terms (e.g. fly OR drosophila) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. dros* for partial matches or fly AND NOT embryo to exclude a term

Search results 7801 to 7900 out of 30763 for seed protein

Category restricted to ProteinDomain (x)

<< First    < Previous  |  Next >    Last >>
0.028s

Categories

Category: ProteinDomain
« show all
Type Details Score
Protein Domain
IPR035158
Name: Protein of unknown function DUF5396
Type: Family
Description: This is a family of unknown function found in Mycoplasma.
•
•
•
•
•
Protein Domain
IPR035192
Name: Nuclear pore complex protein NUP160
Type: Domain
Description: This C-terminal domain includes a predicted nucleoporin, NUP160, from Arabidopsis [ ]. NUP160 is required for nuclear mRNA export and for disease resistance [, ] and for proper expression of factors responsible for the repression of auxin signalling [].
•
•
•
•
•
Protein Domain
IPR035194
Name: Protein of unknown function DUF5461
Type: Family
Description: This is a family of unknown function found in Sulfolobus viruses.
•
•
•
•
•
Protein Domain
IPR035196
Name: Protein of unknown function DUF5312
Type: Family
Description: This is a family of unknown function, mostly found in Spirochaetia.
•
•
•
•
•
Protein Domain
IPR035197
Name: Protein of unknown function DUF5313
Type: Family
Description: This is a family of unknown function, found mostly in Actinobacteria and composed of trans-membrane proteins.
•
•
•
•
•
Protein Domain
IPR035198
Name: Protein of unknown function DUF5309
Type: Family
Description: This is a family of uncharacterised proteins found in Bacteria.
•
•
•
•
•
Protein Domain
IPR047173
Name: STE20-related kinase adapter protein alpha/beta-like
Type: Family
Description: This family represents a group of pseudokinases including human STE20-related kinase adapter protein alpha/beta (STRADA/B) and related proteins. They contain a domain with similarity to protein kinases but lacks crucial residues for catalytic activity. STRADA/B form a complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) which binds to and activates STK11/LKB1, being STRADA more effective than STRADB [ ]. These proteins adopt a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation [].
•
•
•
•
•
Protein Domain
IPR011416
Name: Predicted RNA-binding protein YdrC-type, Chlamydia
Type: Family
Description: This group contains homologues of Escherichia coli YrdC with an additional unique short (~100 aa) C-terminal domain. In accordance with its proposed role as a translation factor, YrdC preferentially binds dsRNA, likely via a depression on the surface of the protein [ ]. However, members of both this group lack the C-terminal domain that has been shown to be essential for the regulatory (probably translational) function of the related two-domain protein SUA5 () [ ].
•
•
•
•
•
Protein Domain
IPR023402
Name: Uncharacterised protein MG237, central domain
Type: Homologous_superfamily
Description: This entry represents the central domain found in hypothetical protein mg237 [ ].
•
•
•
•
•
Protein Domain
IPR011458
Name: Protein of unknown function DUF1564
Type: Family
Description: This is a family of paralogous proteins in Leptospiraceae. One of them (e.g. ) have been annotated as possible CopG-like transcriptional regulators (see ).
•
•
•
•
•
Protein Domain
IPR011457
Name: Protein of unknown function DUF1563
Type: Family
Description: This family of proteins is functionally uncharacterised.
•
•
•
•
•
Protein Domain
IPR035428
Name: Fanconi anemia group F protein
Type: Family
Description: Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [ , ].Fanconi anemia group F protein (FANCF) is a component of the FA core complex [ , ]. FANCF regulates its own expression by methylation at both mRNA and protein levels. Methylation-induced inactivation of FANCF has an important role on the occurrence of ovarian cancers by disrupting the FA-BRCA pathway [].This entry also includes homologues from plants.
•
•
•
•
•
Protein Domain
IPR011450
Name: Protein of unknown function DUF1556
Type: Family
Description: This is a family of proteins of unknown function.
•
•
•
•
•
Protein Domain
IPR011455
Name: Protein of unknown function DUF1561
Type: Family
Description: This is a family of uncharacterised proteins.
•
•
•
•
•
Protein Domain
IPR011453
Name: Protein of unknown function DUF1559
Type: Family
Description: This is a large family of paralogous proteins apparently unique to planctomycetes.
•
•
•
•
•
Protein Domain
IPR035415
Name: Protein of unknown function DUF5382
Type: Family
Description: This is a family of unknown function found in Caenorhabditis.
•
•
•
•
•
Protein Domain
IPR011467
Name: Protein of unknown function DUF1573
Type: Family
Description: These hypothetical proteins from bacteria, such as Rhodopirellula baltica, Bacteroides thetaiotaomicron and Porphyromonas gingivalis, share a region of conserved sequence towards their N termini.
•
•
•
•
•
Protein Domain
IPR035416
Name: Protein of unknown function DUF5376
Type: Family
Description: This is a family of unknown function found in Bacteria.
•
•
•
•
•
Protein Domain
IPR011468
Name: Protein of unknown function DUF1574
Type: Family
Description: This is a family of hypothetical proteins found in Leptospira interrogans and other bacteria.
•
•
•
•
•
Protein Domain
IPR011460
Name: Protein of unknown function DUF1566
Type: Family
Description: These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.
•
•
•
•
•
Protein Domain
IPR011465
Name: Protein of unknown function DUF1571
Type: Family
Description: This is a family of paralogous proteins found in Planctomycetacia and Betaproteobacteria.
•
•
•
•
•
Protein Domain
IPR011466
Name: Protein of unknown function DUF1572
Type: Family
Description: This protein represents proteins with unknown function found in several diverse bacteria.
•
•
•
•
•
Protein Domain
IPR011463
Name: Protein of unknown function DUF1569
Type: Family
Description: This entry represents a family of hypothetical proteins identified in Rhodopirellula baltica and other bacteria.
•
•
•
•
•
Protein Domain
IPR035406
Name: Protein of unknown function DUF5412
Type: Family
Description: This is a family of unknown function found in bacteria. Members of this family have one or two predicted trans-membrane regions.
•
•
•
•
•
Protein Domain
IPR035407
Name: Protein of unknown function DUF5399
Type: Family
Description: This is a family of unknown function mostly found in Chlamydiia.
•
•
•
•
•
Protein Domain
IPR035409
Name: Seminal vesicle secretory protein 4/5/6
Type: Family
Description: There are seven major proteins involved in murine seminal vesicle secretion (SVS1-7). Mouse Svs2/Svs6 genes evolved by gene duplication and belong to the same gene family [ ]. This entry represents SVS4/5 and 6. SVS4 is a basic, thermostable, secretory protein synthesized by rat seminal vesicle epithelium under strict androgen transcriptional control. This protein has potent nonspecies-specific immunomodulatory, anti-inflammatory, and pro-coagulant activities that have been shown to be located in the N-terminal region of Svs4 (fragment 1-70) []. The N-terminal segment has a high amino-acid sequence similarity with the C-terminal segment 34-66 of uteroglobin, a rabbit steroid-inducible, cytokine-like, multifunctional, secreted protein. Furthermore, SVS4 acts as a sperm capacitation inhibitor, by interacting with SVS3 and SVS2 [].
•
•
•
•
•
Protein Domain
IPR011432
Name: Heme-binding protein Shr-like, Hb-interacting domain
Type: Domain
Description: This entry represents the Hb-interacting domain (HID), which is found duplicated in Heme-binding protein Shr from Streptococcus pyogenes, a potentially lethal human pathogen, and in one to six copies in other uncharacterised bacterial proteins. Shr is a virulence factor that captures Hb and binds to the oxidized form of heme through an N-terminal region that contains two copies of this domain. HID shows a β-sandwich-type fold in which two antiparallel β-sheets are flanked by an α-helix [ ].
•
•
•
•
•
Protein Domain
IPR011447
Name: Protein of unknown function DUF1552
Type: Family
Description: This is a family of uncharacterized proteins first identified in the Planctomycete Rhodopirellula baltica.
•
•
•
•
•
Protein Domain
IPR011473
Name: Protein of unknown function DUF1579
Type: Family
Description: This is a family of paralogous hypothetical proteins identified in Rhodopirellula baltica that also has members in Gloeobacter violaceus, Rhizobium meliloti and Agrobacterium tumefaciens, amongst others.
•
•
•
•
•
Protein Domain
IPR011470
Name: Protein of unknown function DUF1576
Type: Family
Description: This small family has no known function. Their sequences frequently contain conserved glycine and aromatic residues.
•
•
•
•
•
Protein Domain
IPR011471
Name: Protein of unknown function DUF1577
Type: Family
Description: This is a family of hypothetical proteins found in Leptospiraceae.
•
•
•
•
•
Protein Domain
IPR011476
Name: Protein of unknown function DUF1582
Type: Family
Description: This is a family of hypothetical proteins found in Rhodopirellula.
•
•
•
•
•
Protein Domain
IPR011474
Name: Protein of unknown function DUF1580
Type: Family
Description: This is a family of short hypothetical proteins found in Rhodopirellula baltica.
•
•
•
•
•
Protein Domain
IPR011480
Name: Protein of unknown function DUF1589
Type: Family
Description: This is a family of short hypothetical proteins found in Rhodopirellula baltica.
•
•
•
•
•
Protein Domain
IPR011487
Name: Protein of unknown function DUF1598
Type: Family
Description: This is a family of Planctomycetales hypothetical proteins of about 500 amino acids in length.
•
•
•
•
•
Protein Domain
IPR013904
Name: Transcriptional regulatory protein RXT2, N-terminal
Type: Domain
Description: The entry represents the N-terminal region of RXT2. RXT2, also known as RAF60, is a component of the Rpd3 histone deacetylase complex (HDAC). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events [ ].
•
•
•
•
•
Protein Domain
IPR037929
Name: DCC-interacting protein 13-alpha, BAR domain
Type: Domain
Description: Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing (APPL) proteins are effectors of the small GTPase Rab5 that function in endosome-mediated signaling [ , ]. They contain BAR, pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains. They form homo- and hetero-oligomers that are mediated by their BAR domains []. Vertebrates contain two APPL proteins, DCC-interacting protein 13-alpha and beta (DP13A and B, also known as APPL1 and APPL2, respectively). DP13A interacts with diverse receptors (e.g. NGF receptor TrkA, FSHR, adiponectin receptors) and signaling proteins (e.g. Akt, PI3K), and function as an adaptor linked to to regulate many processes such as cell proliferation, immune response, endosomal trafficking and cell metabolism [, , ]. This entry represents the BAR domain of DP13A.
•
•
•
•
•
Protein Domain
IPR025942
Name: Stage VI sporulation protein F
Type: Family
Description: The sporulation-specific SpoVIF (YjcC) protein of Bacillus subtilis is essential for the development of heat-resistant spores. Its expression is governed by SigK [ , ].
•
•
•
•
•
Protein Domain
IPR025914
Name: Stage V sporulation protein AE
Type: Family
Description: This entry represents stage V sporulation protein AE [ ].
•
•
•
•
•
Protein Domain
IPR035308
Name: Protein of unknown function DUF5368
Type: Family
Description: This is a family of unknown function found in Proteobacteria and predicted to contain 2 trans-membrane regions.
•
•
•
•
•
Protein Domain
IPR035303
Name: Protein of unknown function DUF5364
Type: Family
Description: This family of unknown function is found in Saccharomycetales.
•
•
•
•
•
Protein Domain
IPR035340
Name: Protein of unknown function DUF5425
Type: Family
Description: This is a family of unknown function found in Borreliella.
•
•
•
•
•
Protein Domain
IPR035346
Name: Protein of unknown function NinD
Type: Family
Description: This is a family of unknown function found in phages such as Enterobacteria phage P22 and Enterobacteria phage lambda.
•
•
•
•
•
Protein Domain
IPR035339
Name: Protein of unknown function DUF5426
Type: Family
Description: This is a family of unknown function found in Mycoplasma.
•
•
•
•
•
Protein Domain
IPR035332
Name: Protein of unknown function DUF5386
Type: Family
Description: This is a family of unknown function found in Chromadorea.
•
•
•
•
•
Protein Domain
IPR035333
Name: Protein of unknown function DUF5389
Type: Family
Description: This is a family of unknown function found mostly in Pasteurellaceae. Family members are predicted to have 3 trans-membrane regions.
•
•
•
•
•
Protein Domain
IPR035334
Name: Protein of unknown function DUF5390
Type: Family
Description: This is a family of unknown function found in Caenorhabditis.
•
•
•
•
•
Protein Domain
IPR035335
Name: Protein of unknown function DUF5397
Type: Family
Description: This is a family of unknown function mostly found in Proteobacteria.
•
•
•
•
•
Protein Domain
IPR035336
Name: Protein of unknown function DUF5398
Type: Family
Description: This is a family of unknown function mostly found in Chlamydiia.
•
•
•
•
•
Protein Domain
IPR035321
Name: Protein of unknown function DUF5373
Type: Family
Description: This family of unknown function is found in Caenorhabditis. Members of this family are predicted to contain 4 trans-membrane regions.
•
•
•
•
•
Protein Domain
IPR035322
Name: Male Flower Specific protein 18
Type: Family
Description: In Maize, MFS18 mRNA accumulates in the glumes and in anther walls, paleas and lemmas of mature florets. It is particularly associated with the vascular bundle in the glumes and encodes a polypeptide of 12kDa, rich in glycine, proline and serine that has similarities with other plant structural proteins [ ]. There is no known function of this domain family in Maize or other Poaceae.
•
•
•
•
•
Protein Domain
IPR035324
Name: Protein of unknown function DUF5381
Type: Family
Description: This is a family of unknown function mostly found in Bacillales.
•
•
•
•
•
Protein Domain
IPR035325
Name: Protein of unknown function DUF5385
Type: Family
Description: This is a family of unknown function found in Mycoplasmataceae. Family members are predicted to have one trans-membrane region.
•
•
•
•
•
Protein Domain
IPR035315
Name: Protein of unknown function DUF5372
Type: Family
Description: This family of unknown function is mostly found in Bacteria.
•
•
•
•
•
Protein Domain
IPR035317
Name: Protein of unknown function DUF5375
Type: Family
Description: This is a family of unknown function found in Enterobacteriaceae.
•
•
•
•
•
Protein Domain
IPR035318
Name: Protein of unknown function DUF5377
Type: Family
Description: This is a family of unknown function found in Pasteurellaceae.
•
•
•
•
•
Protein Domain
IPR035319
Name: Protein of unknown function DUF5378
Type: Family
Description: This is a family of unknown function found in Mycoplasmataceae. Family members are predicted to contain 7 trans-membrane regions
•
•
•
•
•
Protein Domain
IPR035313
Name: Transferrin-binding protein B, N-lobe handle
Type: Domain
Description: Bacterial lipoproteins represent a large group of specialized membrane proteins that perform a variety of functions including maintenance and stabilization of the cell envelope, protein targeting and transit to the outer membrane, membrane biogenesis, and cell adherence [ ]. Pathogenic Gram-negative bacteria within the Neisseriaceae and Pasteurellaceae families rely on a specialized uptake system, characterized by an essential surface receptor complex that acquires iron from host transferrin (Tf) and transports the iron across the outer membrane. They have an iron uptake system composed of surface exposed lipoprotein, Tf-binding protein B (TbpB), and an integral outer-membrane protein, Tf-binding protein A (TbpA), that together function to extract iron from the host iron binding glycoprotein (Tf). TbpB is a bilobed (N and C lobe) lipid-anchored protein with each lobe consisting of an eight-stranded beta barrel flanked by a 'handle' domain made up of four (N lobe) or eight (C lobe) beta strands [ ]. TbpB extends from the outer membrane surface by virtue of an N-terminal peptide region that is anchored to the outer membrane by fatty acyl chains on the N-terminal cysteine, and is involved in the initial capture of iron-loaded Tf []. The 4-residue conserved LSAC motif found at the amino terminus of TbpB represents a prototypical lipobox, with the cysteine residue serving as the first amino acid in the mature protein which is subsequently modified by the addition of a diacyl glycerol. A second conserved motif of interest is located two amino acids downstream of the LSAC site. This region consists of four glycine residues in tandem. Deletion of the conserved polyglycine motif has significant negative effects on growth in certain conditions, while mutational analysis revealed that the LSAC motif constituting the lipobox of TbpB is necessary for lipidation and hence tethering of TbpB to the bacterial surface [].This entry represents a domain found on the N-terminal region of TbpB proteins, which comprises the N-lobe handle consisting of a four-stranded antiparallel beta sheets held together by a short surface-exposed alpha helix. Tf-binding activity primarily resides in the TbpB N lobe [ ].
•
•
•
•
•
Protein Domain
IPR035314
Name: Protein of unknown function DUF5370
Type: Family
Description: This is a family of unknown function found in Bacillaceae.
•
•
•
•
•
Protein Domain
IPR035387
Name: Protein of unknown function DUF5406
Type: Family
Description: This is a family of unknown function mostly found in Bacteria.
•
•
•
•
•
Protein Domain
IPR035389
Name: Protein of unknown function DUF5411
Type: Family
Description: This is a family of unknown function found in Bacteria.
•
•
•
•
•
Protein Domain
IPR035360
Name: Protein of unknown function DUF5420
Type: Family
Description: This is a family of unknown function mainly found in Gammaproteobacteria.
•
•
•
•
•
Protein Domain
IPR035365
Name: Protein of unknown function DUF5407
Type: Family
Description: This is a family of unknown function mostly found in Chlamydiia.
•
•
•
•
•
Protein Domain
IPR035366
Name: Protein of unknown function DUF5408
Type: Family
Description: This is a family of unknown function found in Helicobacteraceae. Family members are predicted to contain one trans-membrane region.
•
•
•
•
•
Protein Domain
IPR035359
Name: Protein of unknown function DUF5421
Type: Family
Description: This is a family of unknown function found in Chlamydia.
•
•
•
•
•
Protein Domain
IPR035350
Name: Protein of unknown function DUF5400
Type: Family
Description: This is a family of unknown function found in Euryarchaeota. Members of this family are predicted to contain 4 trans-membrane regions.
•
•
•
•
•
Protein Domain
IPR035354
Name: Protein of unknown function DUF5424
Type: Family
Description: This is a family of unknown function specific to Rickettsia.
•
•
•
•
•
Protein Domain
IPR035355
Name: Protein of unknown function DUF5423
Type: Family
Description: This is a family of unknown function found in Chlamydia. Family members have 4 predicted trans-membrane regions.
•
•
•
•
•
Protein Domain
IPR035358
Name: Protein of unknown function DUF5422
Type: Family
Description: This is a family of unknown function found in Chlamydia. Members of this family have 1-4 predicted trans-membrane regions.
•
•
•
•
•
Protein Domain
IPR035392
Name: Protein of unknown function DUF5417
Type: Family
Description: This is a family of unknown function found in Proteobacteria and virus.
•
•
•
•
•
Protein Domain
IPR035393
Name: Protein of unknown function DUF5416
Type: Family
Description: This is a family of unknown function found in Campylobacteria.
•
•
•
•
•
Protein Domain
IPR035395
Name: Protein of unknown function DUF5415
Type: Family
Description: This is a family of unknown function found in Enterococcus.
•
•
•
•
•
Protein Domain
IPR035399
Name: Protein of unknown function DUF5413
Type: Family
Description: This is a family of unknown function found in Bradyrhizobiaceae. Family members contain 3 or 4 predicted trans-membrane regions.
•
•
•
•
•
Protein Domain
IPR008003
Name: Protein of unknown function DUF739
Type: Family
Description: This entry includes Bacteriophage bIL285, Orf5. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.This family contains several bacteriophage proteins. Three of the proteins in this family have been labelled putative cro repressor proteins.
•
•
•
•
•
Protein Domain
IPR008014
Name: Glycogen synthase kinase-3 binding protein
Type: Family
Description: Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates four serine residues on glycogen synthase (GS), in the sequence SxxxSxxxSxxx-SxxxS(p), by recognising andphosphorylating the first serine in the sequence motif SxxxS(P) (where S(p) represents a phosphoserine). Interaction of GSK-3 with a peptide derived from GSK-3 binding proteinprevents GSK-3 interaction with Axin. This interaction thereby inhibits the Axin-dependent phosphorylation of beta-catenin by GSK-3 [].
•
•
•
•
•
Protein Domain
IPR008018
Name: Bacteriophage tail attachment protein FII
Type: Family
Description: The phage head-tail attachment protein is required for the joining of phage heads and tails at the last step of morphogenesis [ ]. FII is incorporated into the base vertex of DNA-filled heads to facilitate head-tail joining and may determine the specificity of tail attachment. There are 5-6 copies of protein FII per mature phage.
•
•
•
•
•
Protein Domain
IPR011631
Name: Protein of unknown function DUF1600
Type: Family
Description: These proteins appear to be specific to Mycoplasma species. They are of unknown function.
•
•
•
•
•
Protein Domain
IPR008023
Name: Protein of unknown function DUF748
Type: Family
Description: This is a family of proteins of unknown function.
•
•
•
•
•
Protein Domain
IPR023661
Name: Bifunctional F420 biosynthesis protein FbiB
Type: Family
Description: FbiB catalyses the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives [ , , , ]. It is also involved in the FMNH2-dependent reduction of dehydro-F420-0 to form F420-0 []. This entry represents the bacterial form of the enzyme.
•
•
•
•
•
Protein Domain
IPR021008
Name: Protein of unknown function DUF3687
Type: Family
Description: Proteins in this family are bacterial proteins of approximately 50 amino acids in length. There are two completely conserved residues (L and Y) that may be functionally important. A number of entries are annotated as D-Ala-teichoic acid biosynthesis protein; however there is no direct evidence to support this annotation.
•
•
•
•
•
Protein Domain
IPR011670
Name: Protein of unknown function DUF1612
Type: Family
Description: This family includes sequences of largely unknown function but which share a number of features in common. They are expressed by bacterial species, and in many cases these bacteria are known to associate symbiotically with plants. Moreover, the majority are coded for by plasmids, which in many cases are known to confer on the organism the ability to interact symbiotically with leguminous plants. An example of such a plasmid is NGR234, which encodes Y4CF, a protein of unknown function that is a member of this family [ ]. Other members of this family are expressed by organisms with a documented genomic similarity to plant symbionts [].
•
•
•
•
•
Protein Domain
IPR011675
Name: Protein of unknown function DUF1617
Type: Family
Description: This family of proteins is currently uncharacterised.
•
•
•
•
•
Protein Domain
IPR011672
Name: Protein of unknown function DUF1614
Type: Family
Description: This is a family of sequences coming from hypothetical proteins found in both bacterial and archaeal species.
•
•
•
•
•
Protein Domain
IPR011673
Name: Protein of unknown function DUF1615
Type: Family
Description: This is a family of proteins of unknown function expressed by various bacterial species. Some members of this family (e.g. , ) are thought to be lipoproteins. Another member of this family ( ) is thought to be involved in photosynthesis [ ].
•
•
•
•
•
Protein Domain
IPR021065
Name: Fertility inhibition protein FinO, N-terminal
Type: Domain
Description: This entry represents the N-terminal of the Fertility inhibition protein FinO, found in bacteria, and is typically between 62 and 102 amino acids in length. The FinOP (fertility inhibition) system of F-like plasmids consists of an antisense RNA (FinP) and a 22kDa protein (FinO) which act in concert to prevent the translation of TraJ, the positive regulator of the transfer operon [ ].
•
•
•
•
•
Protein Domain
IPR033023
Name: Glutaredoxin domain-containing cysteine-rich protein 2
Type: Family
Description: Glutaredoxin domain-containing cysteine-rich protein 2 (GRXCR2) may be involved in the development of stereocilia bundles, specialised structures on the apical surface of sensory cells in the cochlea that are critical for sound detection [ ].
•
•
•
•
•
Protein Domain
IPR021045
Name: Influenza A proapoptotic protein PB1-F2
Type: Family
Description: PB1-F2 is a protein found in almost all known strains of Influenza A virus - a negative sense ssRNA Orthomyxovirus [ ]. It originates from translation of the viral polymerase gene in an alternative reading frame []. PB1-F2 consists of two independent structural domains, two closely neighbouring short helices at the N terminus, and an extended C-terminal helix []. Although the protein has originally been described to induce apoptosis, it has now been shown that PB1-F2 more likely acts as an apoptosis promoter in concert with other apoptosis-inducing agents []. PB1-F2 promotes apoptosis by localising to the mitochondria where it destabilises the membrane. This will cause release of cytochrome C which activates the caspase cascade of apoptosis through the endogenous pathway []. In this way it acts like the Bcl-2 protein family which are physiological apoptotic regulators in cells [].
•
•
•
•
•
Protein Domain
IPR021048
Name: Intracellular growth locus C protein
Type: Family
Description: IglC protein is involved in the escape of Francisella tularensis live vaccine strain [ ]. It has been shown that the expression of IglC is essential for F. tularensis to induce macrophage apoptosis []. IglC adopts a β-sandwich conformation that has no similarity to any known protein structure [].
•
•
•
•
•
Protein Domain
IPR021030
Name: Protein of unknown function DUF3731
Type: Family
Description: Proteins in this family are bacterial proteins of approximately 250 amino acids in length. There are two conserved sequence motifs: RPG and WRR. The proteins in this family are frequently annotated as DNA-K related proteins however there is little accompanying literature to confirm this.
•
•
•
•
•
Protein Domain
IPR021076
Name: Parvovirus non-structural protein 1, N-terminal
Type: Domain
Description: Parvoviruses are some of the smallest viruses containing linear, non-segmented single-stranded DNA genomes, with an average genome size of 5000 nucleotides. Parvoviruses have been described that infect a wide range of invertebrates and vertebrates and are well known for causing enteric disease in mammals. Genomes contain two large ORFs: NS1 and VP1; other ORFs are found in some sub-types and different gene products can arise from splice variants and the use of different start codons [ , ].This entry represents a domain of the parvovirus Initiator protein 1 (NS1, also known as non-structural protein 1). It is found immediately N-terminal to the helicase domain and binds to the origin of replication [ ]. Parvoviral NS1 regulates host gene expression through histone acetylation [].
•
•
•
•
•
Protein Domain
IPR045095
Name: Ancient conserved domain protein family
Type: Family
Description: Proteins containing the ancient conserved domain protein/cyclin M (CNNM) are integral membrane proteins that are conserved from bacteria to humans. CNNM family members influence metal ion homeostasis through mechanisms that may not involve direct membrane transport of the ions [ , , , ]. Structurally, CNNMs contain large cytosolic regions composed of a CBS-pair and a cyclic nucleotide-binding homology (CNBH) domain []. In mammals, the CNNM family consists of 4 integral membrane proteins (CNNM1-4). NNM-associated Mg2+ transport has been shown shown to be regulated by the binding of phosphatases of regenerating liver (PRLs). PRLs are potent oncogenes with strong association with metastatic cancers [, ]. In Caenorhabditis elegans, there are five CNNM family members that may work together to regulate Mg2+ homeostasis [].
•
•
•
•
•
Protein Domain
IPR045096
Name: Protein ENHANCED DISEASE RESISTANCE 2-like
Type: Family
Description: This entry includes EDR2 and EDR2L from Arabidopsis. They contain a pleckstrin homology and a StAR transfer (START) domain as well as a plant-specific domain of unknown function, DUF1336. EDR2 is a negative regulator of the salicylic acid- (SA-) mediated resistance to pathogens, including the biotrophic powdery mildew pathogens Golovinomyces cichoracearum and Blumeria graminis, and the downy mildew pathogen Hyaloperonospora parasitica, probably by limiting the initiation of cell death and the establishment of the hypersensitive response (HR) [ , ].
•
•
•
•
•
Protein Domain
IPR035539
Name: Protein of unknown function DUF5387
Type: Family
Description: This is a family of unknown function mostly found in Rhabditida.
•
•
•
•
•
Protein Domain
IPR023558
Name: Tryptophan RNA-binding attenuator protein domain
Type: Domain
Description: The tryptophan RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic genes in Bacillus sp. by binding to the leader region of the nascent trp operon mRNA [ ]. The crystal structure of the Trp RNA-binding attenuation protein of Bacillus subtilis (mtrB, ) has been solved [ ]. TRAP forms an oligomeric ring consisting of 11 single-domain subunits, where each subunit adopts a double-stranded β-helix structure with the appearance of a β-sandwich of distinct architecture and jelly-roll fold. The 11 subunits are stabilised by 11 inter-subunit strands, forming a β-wheel with a large central hole. TRAP is activated by binding to tryptophan in clefts between adjacent β-strands, which induces conformational changes in the protein. Activated TRAP binds an mRNA target sequence consisting of 11 (G/U)AG repeats, separated by 2-3 spacer nucleotides. The spacer nucleotides do not make direct contact with the TRAP protein, but they do influence the conformation of the RNA, which might influence the specificity of TRAP [].This entry represents the structural domain in the TRAP family of proteins.
•
•
•
•
•
Protein Domain
IPR035530
Name: Phage-like element PBSX protein XtrA
Type: Family
Description: This is a family of unknown function mostly found in Bacilli.
•
•
•
•
•
Protein Domain
IPR035528
Name: Protein of unknown function DUF5388
Type: Family
Description: This is a family of unknown function found mostly in Lactobacillales.
•
•
•
•
•
Protein Domain
IPR035582
Name: Protein of unknown function DUF5418
Type: Family
Description: This is a family of unknown function found in Methanocaldococcus jannaschii. Family members have three predicted trans-membrane regions.
•
•
•
•
•
Protein Domain
IPR023847
Name: Conserved hypothetical protein CHP04044, MSMEG0572
Type: Family
Description: This entry describes a family of proteins with remote similarity to the DsrE/DsrF-like family (see ). All members are found in a context of at least seven genes that includes a radical SAM protein, suggesting biosynthesis. The system is sparsely but broadly distributed in bacteria, including Actinobacteria, Proteobacteria, and Cyanobacteria.
•
•
•
•
•
Protein Domain
IPR023846
Name: Conserved hypothetical protein CHP04042, MSMEG0570
Type: Family
Description: This entry represents small proteins of about 90 residues long that have no detectable homologues outside this family. These proteins serve as markers for an eight-gene region whose overall function is unknown. One member of the cluster is a radical SAM protein with some similarity to enzymes of cofactor biosynthesis, another a glycosyltransferase, several represent hydrolases or oxidoreductases, and several unknown proteins.
•
•
•
•
•
Protein Domain
IPR011863
Name: Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein
Type: Family
Description: This protein is has been characterised as both a phosphoserine phosphatase and a phosphoserine:homoserine phosphotransferase [ ]. In Pseudomonas aeruginosa, where the characterisation was done, a second phosphoserine phosphatase (SerB) and a second homoserine kinase (thrB) are found, but in Fibrobacter succinogenes neither are present.
•
•
•
•
•
USDA
InterMine logo
The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
LegumeMine || ArachisMine | CicerMine | GlycineMine | LensMine | LupinusMine | PhaseolusMine | VignaMine | MedicagoMine
InterMine © 2002 - 2022 Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom