Protein Domain : Growth arrest/ DNA-damage-inducible protein-interacting protein 1 IPR018472

Type  Family
Description  Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity [ ]. They may be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.
Short Name  Damage-induce-interacting_prot

0 Child Features

0 Gene Families

0 Genes

1 Ontology Annotations

0 Parent Features

0 Publications

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