Protein Domain : Tight junction-associated protein 1 domain IPR043470

Type  Domain
Description  This domain is found in members of the Tight junction-associated protein 1 (Tjap1) family, also known as Pilt family, a family of eukaryotic tight junction-proteins [ ]. Pilt is a component of Tight junctions (TJs) rather than Adhesin junctions (AJs). TJs function as a barrier preventing solutes and water from passing freely through the paracellular pathway. TJs consist of transmembrane proteins (claudin, occludin, and JAM) plus many peripheral membrane proteins and cell polarity molecules.Pilt is a novel peripheral membrane protein which is incorporated into TJs after TJ strands are formed, thereby the name Pilt stands for 'protein incorporated later into TJs'. Pilt binds to the guanylate-kinase region of disk large homologue/synapse-associated protein 97 (hDlg/SAP97) [ ].
Short Name  Tjap1_dom

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