Protein Domain : RNA-binding protein MEX-3, first type I KH domain IPR047228

Type	Domain
Description	This entry represents the first type I KH domain of MEX3 proteins. The MEX-3 protein family includes four members, MEX3A/RKHD4, MEX3B/RKHD3/RNF195, MEX3C/ RKHD2/RNF194, and MEX3D/RKHD1/RNF193/TINO [ , , ]. They are homologous of Caenorhabditis elegans MEX-3 protein, a translational regulator that specifies the posterior blastomere identity in the early embryo and contributes to the maintenance of the germline totipotency [, ]. MEX-3 proteins are RNA-binding phosphoproteins involved in post-transcriptional regulatory mechanisms [, , ]. It has been shown that these proteins are deregulated in several cancers and affects apoptosis regulation, antigen processing, and presentation, which, therefore, contribute to the immune evasion of tumour cells [, ].They are characterised by containing two K-homology (KH) RNA-binding domains and a C-terminal RING finger [ ]. They bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1-dependent export pathway [].
Short Name	KH-I_MEX3_rpt1