LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | This entry represents the first type I K homology (KH) RNA-binding domain found in Nova-1 and Nova-2.This group of proteins includes related neuronal RNA-binding proteins, such as Nova-1 and Nova-2. Nova-1 may regulate RNA splicing or metabolism in a specific subset of developing neurons. It interacts with RNA containing repeats of the YCAY sequence. It is a brain-enriched splicing factor regulating neuronal alternative splicing. Nova-1 is involved in neurological disorders and carcinogenesis. Nova-2 is a neuronal RNA-binding protein expressed in a broader central nervous system (CNS) distribution than Nova-1. It functions in neuronal RNA metabolism. NOVA family proteins contain three K-homology (KH) RNA-binding domains [ , , , , , , , , , ]. This entry also includes the homologue of Nova1 in Drosophila melanogaster, also know as RNA-binding protein Pasilla, which plays a role in long-term memory formation by processing the unspliced Orb2-isoform A (Orb2A) mRNA and thereby controlling Orb2A protein abundance [ , ]. |
| Short Name | KH-I_NOVA_rpt1 |
