Protein Domain : Chitin biosynthesis protein Chs5, N-terminal IPR031673

Type	Domain
Description	This domain is found at the N terminus of fungal chitin biosynthesis protein Chs5 [ ]. It functions as a dimerisation domain [].Chs5/6 is a multi-protein complex conserved in fungi that interacts with chitin synthase III (Chs3p) and is involved in its transport to the cell surface from the trans-Golgi network, functioning as an exomer cargo adapter. Chs5p appears to form a complex with Chs6p and its paralogues Bch1p, Bud7p, and Bch2p. In this complex, Chs5p may act as a central scaffold [ ]. The N-terminal domain characterized by this model forms a homodimer and has been shown to interact with Chs6p and Bch1p. It may function as a flexible hinge domain that allows the exomer to interact with both proteins and the Golgi membrane as the latter undergoes changes in curvature during the formation of transport vesicles []. The dimerization domain sits N-terminally to a conserved FBE (FN3-BRCT) unit, which binds Arf1 an is involved in the recruitment of the exomer to the membrane [].
Short Name	Chs5_N