Protein Domain : LKB1 serine/threonine kinase interacting protein 1, N-terminal IPR031782

Type  Domain
Description  This domain represents the N terminus of LIP1, a leucine-rich-repeat protein that interacts with kinase LKB1/STK11, implicated in Peutz-Jeghers syndrome. LIP1 (LKB1 serine/threonine kinase interacting protein 1), also known as STK11IP, interacts with the TGF-beta-regulated transcription factor SMAD4 to form a LKB1-LIP1-SMAD4 ternary complex. Mutations in SMAD4 lead to juvenile polyposis, suggesting a mechanistic link between these two diseases [ , ].
Short Name  LIP1_N
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