Protein Domain : GTP-binding protein BipA, domain 2 IPR047042

Type	Domain
Description	BipA (also called TypA) is a highly conserved protein with global regulatory properties in Escherichia coli. Mutants show altered regulation of some pathways. BipA is a 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures and it also functions as a translation factor that is required specifically for the expression of the transcriptional modulator Fis. BipA binds to ribosomes at a site that coincides with that of EF-G and has a GTPase activity that is sensitive to high GDP:GTP ratios and is stimulated by 70S ribosomes programmed with mRNA and aminoacylated tRNAs [ , ]. The growth rate-dependent induction of BipA allows the efficient expression of Fis, thereby modulating a range of downstream processes, including DNA metabolism and type III secretion. This GTPase impacts interactions between enteropathogenic E.coli (EPEC) and epithelial cells and also has an effect on motility [ ]. It appears to be involved in the regulation of several processes important for infection, including rearrangements of the cytoskeleton of the host, bacterial resistance to host defence peptides, flagellum-mediated cell motility, and expression of K5 capsular genes [, ].This entry also includes TypA-like SVR3 from Arabidopsis, a putative chloroplastic elongation factor involved in response to chilling stress. It is required for proper chloroplast rRNA processing and/or translation at low temperature [ ] and it is also involved in plastid protein homeostasis [].This entry represents domain II of BipA/TypA, which shows similarity to the domain II of the elongation factors (EFs) EF-G and EF-Tu [ , ].
Short Name	BipA_II