Protein Domain : TAR DNA-binding protein 43, N-terminal IPR041105

Type	Domain
Description	This domain can be found at the N-terminal region of transactive response DNA-binding protein 43kDa (TDP-43), an RNA transporting and processing protein whose aberrant aggregates are implicated in neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), Alzheimer's Disease, and frontotemporal dementia [ , ]. TDP-43 N-terminal domain has been shown to play an important role in the aggregation of TDP-43 monomers and its loss of function affects the RNA metabolic levels [, ]. Secondary structure of the N-terminal domain consists of six β-strands and it resembles Axin 1 []. This domain mediates oligomerisation [].
Short Name	TDP43_N