Protein Domain : DCC-interacting protein 13-beta, BAR domain IPR047239

Type	Domain
Description	This entry represents the BAR domain of DCC-interacting protein 13-beta from humans (DIP13B, also known as APPL2) and similar proteins from vertebrates. DIP13B is a multifunctional adapter protein that bind to various membrane receptors, nuclear factors and signalling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism [ , , , , ]. DIP13B may affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor [, ]. These proteins consist of a BAR and a PH domain near the N-terminal, and the two domains are thought to function as a unit (BAR-PH domain) [ ]. At the C-terminal, they have a PTB domain []. Lipid binding assays show that the BAR, PH, and PTB domains can bind phospholipids [].
Short Name	BAR_APPL2