Protein Domain : TOM1-like protein 1, GAT domain IPR027428

Type	Domain
Description	TOM1-like protein 1 (TOM1L1) is an adapter protein involved in signaling pathways. It interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. TOM1L1 promotes activation of Src family tyrosine kinase Fyn, possibly by disrupting intramolecular SH3-dependent interactions [ ]. It has been implicated in multivesicular body (MVB) formation, viral egress from the cell, and cytokinesis. Its amplification enhances the metastatic progression of ERBB2-positive breast cancers [, , ].This entry represents the canonical GAT domain of TOM1L1. It is a monomeric three-helix bundle that binds ubiquitin [ ]. It is also responsible for the interaction with Toll-interacting protein (Tollip) [].
Short Name	TOM1L1_GAT_dom