Protein Domain : Regulator of G-protein signalling 4, RGS domain IPR034953

Type	Domain
Description	RGS4 is a member of R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) [ ]. Signalling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs). RGS4 is expressed widely in brain and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling [ ]. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia [, , ]. RGS4 also is up-regulated in the failing human heart []. RGS4 interacts with many binding partners outside of GPCR pathways, including PIP, calcium/CaM, PA and 14-3-3 [, ].The RGS (Regulator of G-protein Signalling) domain is an essential part of the RGS4 protein.
Short Name	RGS_RGS4