Protein Domain : Regulator of G-protein signalling 5, RGS domain IPR034956

Type	Domain
Description	The RGS (Regulator of G-protein Signalling) domain is an essential part of the RGS5 protein.RGS5 is a member of R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) [ ]. Signalling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).RGS5 may have a role in pericyte (peri-endothelial cell) and vascular smooth muscle cell development and function [ , , ]. It is also expressed is the heart, where it is upregulated by beta-adrenergic mediated induction [].
Short Name	RGS_RGS5