Protein Domain : Nonstructural protein 15, middle domain, coronavirus IPR043608

Type	Domain
Description	The unique coronavirus transcription/replication machinery comprised of multiple virus-encoded non structural proteins (NSP) plays a vital role during initial and intermediate phases of the viral life cycle. NSP15 forms a hexamer made of dimers of trimers which is suggested to be a functional unit, responsible for the endoribonuclease activity. The NSP15 monomer consists of three domains: N-terminal, middle and C-terminal [ , ]. The catalytic function of NSP15 resides in the C-terminal NendoU domain. The active site carries six key residues conserved among SARS-CoV-2, SARS-CoV and MERS-CoV, suggesting that its activity is important for sustained replication in the host [, ].This entry represents the non-catalytic middle domain from NSP15. This domain is formed by ten β-strands organised into threeβ-hairpins. It creates concave surfaces that may serve as interaction hubs with other proteins and RNA [ , ].
Short Name	CoV_NSP15_M