Protein Domain : Phlebovirus glycoprotein G2, C-terminal domain IPR043603

Type	Domain
Description	HRTV is an insect-borne virus found in America that can infect humans. It belongs to the newly defined family Phenuiviridae, order Bunyavirales. HRTV contains three single-stranded RNA segments (L, M, and S). The M segment of the virus encodes a polyprotein precursor that is cleaved into two glycoproteins, Gn and Gc. Gc is a fusion protein facilitating virus entry into host cells [ ]. G2 (also known as Gc) is necessary for optimal glycoprotein G1 (also found as Gn) expression and efficient production or viral-like particles and possibly for the cell infection, as G2 is determinant for cell fusion []. Phleboviral G2 fusion glycoprotein is both functionally and structurally analogous to the fusion glycoproteins of alphaviruses and flaviviruses, all of them recognize DC-SIGN receptor to enable viral attachment [].This domain is found at the C-terminal of several Phlebovirus glycoprotein G2 sequences. Two prefusion conformation structures of bunyavirus Gc from RVFV in the Phenuiviridae family [ ] and Hantaan virus (HTNV) in the Hantaviridae family [] have been solved.
Short Name	Phlebo_G2_C