Protein Domain : Stringent starvation protein A, N-terminal IPR034341

Type	Domain
Description	Stringent starvation protein A (SspA) is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival during nutrient starvation [ ]. SspA adopts the GST fold with an N-terminal TRX-fold domain and a C-terminal alpha helical domain, but it does not bind glutathione (GSH) and lacks GST activity [, ]. SspA is highly conserved among Gram-negative bacteria. Related proteins found in Neisseria (called RegF) [], Francisella and Vibrio regulate the expression of virulence factors necessary for pathogenesis [, ].This entry represents the N-terminal GST-like thioredoxin (TRX) fold domain of the SspA (stringent starvation protein A) protein.
Short Name	SspA_N