Protein Domain : Nonstructural protein 2, N-terminal domain, coronavirus IPR043615

Type  Domain
Description  Coronavirus non-structural protein 2 (NSP2) is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. Viral-host protein interaction studies in SARS-CoV and SARS-CoV-2 found that this protein could interact with several host proteins, including prohibitin 1 (PHB1) and PHB2, which are implicated in a number of cellular functions, including cellular migration, differentiation and apoptosis [ , ]. NSP2 structure from SARS-CoV-2 has been recently solved and revealed that it has three zinc fingers, which may be involved in binding nucleic acids and regulating intracellular signalling pathways []. NSP2 has been pointed as an interesting target to develop anti-SARS-COV-2 therapies as it may play important roles during viral infection.This entry represents the N-terminal of NSP2 which covers the zinc fingers [ ].
Short Name  NSP2_N_CoV

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