Protein Domain : Secreted frizzled-related protein 3, NTR domain IPR035813

Type  Domain
Description  Secreted frizzled-related proteins (Sfrps) are soluble proteins containing an Netrin (NTR) domain C-terminal to a cysteine-rich Frizzled domain [ ]. They show diverse functions and are thought to work in Wnt signaling indirectly, as modulators or antagonists by binding Wnt ligands, and directly, via the Wnt receptor, Frizzled [].SFRP3 (also known as FRZB) regulates chondrocyte maturation and long bone development [ ]. It is an antagonist of Wnt8 signalling [].
Short Name  NTR_Sfrp3

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