Protein Domain : RelA-associated inhibitor IPR028320

Type	Family
Description	This entry represents RelA-associated inhibitor (also known as iASPP), which is a regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins [ ]. iASPP is an ankyrin-repeat-, SH3-domain- and proline-rich-region-containing proteins that is homologous with ASPP1 and ASPP2 (). The ASPPs proteins regulate the apoptotic function of p53; iASPP inhibits p53, whereas ASPP1 and ASPP2 activates p53 [ ]. The p53 tumour suppressor gene is one of the most frequently mutated genes in human cancer that can suppress tumour growth through its ability to induce apoptosis or cell-cycle arrest. Therefore, the ASPP family of proteins may be a novel target for cancer therapy []. This entry also includes ANK repeat-containing protein nipk-1 from the nematode Caenorhabditis elegans, which has been shown to mediate signaling of the receptor complex composed of ilcr-1 and ilcr-2. This complex acts directly on neurons, altering their response properties, modifying behaviour and is the receptor for interleukin-17 [].
Short Name	iASPP