Protein Domain : Apoptosis-stimulating of p53 protein 1, RA domain IPR028319

Type	Domain
Description	ASPP1 (apoptosis-stimulating of p53 protein) is a member of the ASPP protein family (Apoptosi-Stimulating Protein of p53) that activates the p53-mediated apoptotic response. It functions as a tumour suppressor and coordinates with p53 to protect haematopoietic stem cell (HSC) pool integrity, guarding against haematological malignancies [ , , ]. The ASPP family of proteins may be a target for cancer therapy [].This entry represents the RA domain present at the N terminus of ASSP1, which is a ubiquitin-like domain.
Short Name	ASPP1_RA