Protein Domain : Receptor tyrosine-protein phosphatase alpha IPR027262

Type  Family
Description  This entry represents receptor tyrosine-protein phosphatase (PTP) alpha ( ). PTP catalyses the dephosphorylation of protein tyrosine phosphate to protein tyrosine, and appear to play a pivotal role in insulin receptor signalling. It can exist as a single-pass membrane protein or in the cytoplasm. PTP-alpha is as a positive regulator of Src and Src family kinases, acting to dephosphorylate and activate Src. As such, PTP-alpha affects transformation and tumourigenesis, inhibition of proliferation and cell cycle arrest, mitotic activation of Src, integrin signalling, neuronal differentiation and outgrowth, and ion channel activity [ ].
Short Name  Tyr_Pase_rcpt_alpha

0 Child Features

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2 Ontology Annotations

1 Parent Features

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