Protein Domain : Transcriptional enhancer factor TEF-3 (TEAD4) IPR027255

Type	Family
Description	The TEAD family (also known as the TEF family) transcription factors play a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. TEAD transcription factors act by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction [, ].Four TEAD genes exist in mammals (TEAD 1 to 4). TEAD4 protein (also known as TEF-3) was reported to regulate muscle-specific genes in cardiac and smooth muscle cells [ ]. Alternatively spliced transcripts for TEAD4 have been identified in human retinal vascular endothelial cells []. TEAD4 protein has been shown to enhance VEGF gene expression in bovine aortic endothelial cells [].
Short Name	TEF-3