Protein Domain : E3 ubiquitin-protein ligase RNF220, middle domain IPR031824

Type  Domain
Description  This entry represents the central region of the E3 ubiquitin-protein ligase RNF220 [ ]. RNF220 also interacts with beta-catenin independently of its E3 ligase activity; instead of ubiquitinating and destabilising it, RNF220 promotes beta-catenin stabilisation and canonical Wnt signaling []. Proteins containing this domain also include Drosophila Tey protein and some uncharacterised fungal proteins. Tey (Teyrha-Meyhra) is a transcription factor that suppresses Toll expression [].
Short Name  RNF220_mid

0 Child Features

0 Gene Families

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0 Ontology Annotations

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