Protein Domain : Apolipoprotein N-acyltransferase IPR004563

Type	Family
Description	Apolipoprotein N-acyltransferase (Lnt) transfers the acyl group to lipoproteins and is involved in lipoprotein biosynthesis in Gram-negative bacteria. It is an integral membrane protein [ ]. In the last step of lipoprotein maturation, N-acylation by apolipoprotein N-acyltransferase of the plasma membrane is required for recognition of the outer membrane lipoproteins by the Lol system, which transports the lipoproteins from the plasma to the outer membrane []. This is a reverse amidase (i.e. condensation) reaction. This entry also includes bifunctional apolipoprotein N-acyltransferase/polyprenol monophosphomannose synthase from Mycobacterium tuberculosis. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 9 [ , ].
Short Name	Apolipo_AcylTrfase