Protein Domain : Rev protein, Ovine/caprine lentivirus IPR016400

Type	Family
Description	This group represents Rev protein from Ovine/caprine lentiviruses [ ]. The Rev protein escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts) []. This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs, which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs. Rev protein is a homomultimer when bound to RRE, its multimeric assembly being essential for activity.
Short Name	Rev_lentivir