Protein Domain : AP-1 complex subunit sigma IPR044733

Type	Family
Description	The heterotetrameric adaptor protein (AP)-1 complex consists of one large gamma-, one beta-, one mu-, and one sigma-subunit. AP complexes link the cytosolic domains of the cargo proteins to the protein coat that induces vesicle budding in the donor compartment during vesicle transport [ , ]. In the case of AP-1 the coat protein is clathrin. AP-1 binds the phospholipid PI(4)P which plays a role in its localisation to the trans-Golgi network (TGN)/endosome []. This entry represents the sigma subunit, which comprises a single longin domain and plays a role in binding dileucine-based sorting signals.
Short Name	AP1_sigma