Protein Domain : TSP type-3 repeat IPR028974

Type	Homologous_superfamily
Description	This entry represents the calcium-binding type 3 (T3) repeats found in extracellular calcium-binding multifunctional proteins, thrombospondins (TSPs). The T3 repeats lack secondary structure and are organised around a core of calcium ions; two DxDxDGxxDxxD motifs per repeat each encapsulate two calcium ions in a novel arrangement [ ]. TSP type-3 repeat can be found in the following proteins: Cartilage oligomeric matrix protein: may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin [ ].Outer membrane porin F from bacteria [ ]. Alpha-agarase: hydrolyses agarose, agarohexaose, neoagarohexaose and porphyran [ , ].
Short Name	TSP_type-3_rpt