Protein Domain : Geranylgeranyl transferase type-1 subunit beta IPR041960

Type	Family
Description	This entry represents the beta subunit (alpha 6 - alpha 6 barrel fold) of geranylgeranyltransferase type I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain. GGTase-I is a subgroup of the protein prenyltransferase family of lipid-modifying enzymes PTases, which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Prenyltransferases employ a Zn2+ ion to alkylate a thiol group catalyzing the formation of thioether linkages between cysteine residues at or near the C terminus of protein acceptors and the C1 atom of isoprenoid lipids (geranylgeranyl (20-carbon) in the case of GGTase-I) [ ]. GGTase-I prenylates the cysteine in the terminal sequence, 'CAAX' when X is Leu or Phe. Substrates for GTTase-I include the gamma subunit of neural G-proteins and several Ras-related G-proteins [, ]. PTases are heterodimeric with both alpha and beta subunits required for catalytic activity.
Short Name	GGTase_I_beta