LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Family |
| Description | Ectopic expression of vesicular, over-expressed in cancer, pro-survival protein 1, VOPP1 (formerly known as EGFR-co-amplified and over- expressed protein (ECop)) increases NF-kappaB transcriptional activity [ ]. This is achieved by promoting nuclear translocation and DNA binding of NF-kappaB. Ecop-induced NF-kappaB activation confers cellular resistance to apoptotic challenge []. It is believed that ECop is a key regulator of NF-kappaB signalling, and that high-level, amplification-mediated ECop expression, such as occurs in tumours with amplified EGFR, may contribute to resistance to apoptosis []. |
| Short Name | VOPP1 |
