Protein Domain : Alpha-2-macroglobulin, bacteria IPR026284

Type  Family
Description  This family includes uncharacterised protein UPF0192 and uncharacterised lipoprotein yfhM. They contain alpha-2-macroglobulin domains and may be bacterial alpha-2-macroglobulin homologues. The alpha-macroglobulin (aM) family of proteins includes protease inhibitors. The protease inhibiting mechanism involves protease cleavage of the bait region, a segment of the aM that is particularly susceptible to proteolytic cleavage, which initiates a conformational change such that the aM collapses about the protease. In the resulting aM-protease complex, the active site of the protease is sterically shielded, thus substantially decreasing access to protein substrates [ ].
Short Name  A2-macglob_dom_prot_bac

0 Child Features

0 Gene Families

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0 Ontology Annotations

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