Protein Domain : Gamma-synuclein IPR002462

Type	Family
Description	Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors [ , ]. The family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. All synucleins have in common a highly conserved α-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins [].Synuclein family members are not found outside vertebrates, although they have some conserved structural similarity with plant 'late-embryo-abundant' proteins. The alpha- and beta-synuclein proteins are found primarily in brain tissue, where they are seen mainly in presynaptic terminals [ , ]. The gamma-synuclein protein is found primarily in the peripheral nervous system and retina, but its expression in breast tumors [] is a marker for tumor progression [].Normal cellular functions have not been determined for any of the synuclein proteins, although some data suggest a role in the regulation of membrane stability and/or turnover.Mutations in alpha-synuclein are associated with rare familial cases of early-onset Parkinson's disease, and the protein accumulates abnormally in Parkinson's disease, Alzheimer's disease,and several other neurodegenerative illnesses [ ]. As with other synucleins, gamma-synuclein, or persyn, is believed to be involved in the pathogenesis of human neurodegenerative diseases []. Persyn influences neurofilament network integrity [].
Short Name	Synuclein_gamma