Protein Domain : Mesothelin IPR010335

Type	Family
Description	This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, which participates in cell adhesion, tumour progression, metastasis, and drug resistance [ , , ]. This protein is predicted have superhelical structures with ARM-type repeats which suggests that it may act as superhelical lectins to bind the carbohydrate moieties of extracellular glycoproteins []. Due to its overexpression in various tumours, it constitutes a diagnostic and therapy target [].
Short Name	Mesothelin