Protein Domain : Heat shock 70kDa protein 12A, nucleotide-binding domain IPR026685

Type  Domain
Description  Heat shock 70kDa protein 12A (HS12A) is an adapter protein for the amyloid precursor protein receptor SorLA [ ]. As a member of the heat shock protein 70 (HSP70) family of chaperones, HS12A shows a nucleotide-binding domain (NBD, this entry) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. It is predominantly expressed in neuronal cells. and may play a role in the atherosclerotic process []. Mutations in this protein have been related to both schizophrenia and bipolar affective disorder [].
Short Name  HSPA12A_NBD
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