Protein Domain : Intracellular chloride channel IPR002946

Type  Family
Description  The chloride intracellular channel (CLIC) family represent a subgroup of the glutathione-S-transferase (GSTs) superfamily. CLIC proteins can exist as both soluble globular proteins and integral membrane proteins with ion channel function [ ]. Membrane insertion seems to be redox-regulated [] and has a strong pH dependence []. CLIC proteins are enigmatic as they do not fit the patterns of other, well-characterised ion channel proteins that show clear and often multiple TM domains []. They share a conserved C-terminal CLIC module, with several members containing additional, unrelated N-terminal domains. CLIC proteins are highly conserved in vertebrates, which usually possess six distinct paralogues (CLIC1-CLIC6) []. They are multifunctional proteins and participate in a wide variety of signaling activities.
Short Name  CLIC

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