Protein Domain : Salmonella surface presentation of antigen M protein IPR002954

Type	Family
Description	The Salmonella typhimurium Surface Presentation of Antigens M gene (SpaM) is one of 12 that form a cluster responsible for invasion properties [].The gene product is required for entry by the bacterium into epithelial cells, and is thus considered to be a virulence factor []. Other Spa genes in the cluster are related to invasion (Inv) genes in similar Salmonella and Shigella species [], and flagella biosynthesis genes in Helicobacter pylori [].A homologue of this protein has been found recently in Salmonella enterica []. The protein, named InvI, is required by the organism to gain access tomammalian epithelial cells, and cellular mutants (InvI-) failed to successfully infect these cells. It has also been found that the inv-spa loci of this particular species encode for a type III protein secretion system, essential in the bacterium's host cell invasion process [].
Short Name	Salm_SPAgM