Protein Domain : Lateral signaling target protein 2, FYVE domain IPR043269

Type	Domain
Description	Lateral signaling target protein 2 (Lst2) is a monoubiquitinylated phosphoprotein that functions as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Unlike other FYVE domain-containing proteins, Lst2 displays primarily non-endosomal localization. Its endosomal localization is regulated by monoubiquitinylation. Lst2 physically binds Trim3, also known as BERP or RNF22, which is a coordinator of endosomal trafficking and interacts with Hrs and a complex that biases cargo recycling [].This entry represents the FYVE domain of Lst2.
Short Name	FYVE_LST2