Protein Domain : TRIM32, B-box type 1 zinc finger IPR047051

Type	Domain
Description	TRIM32 (also known as 72 kDa Tat-interacting protein, or zinc finger protein HT2A, or BBS11) is an E3 ubiquitin-protein ligase that promotes degradation of several targets, including actin, PIASgamma, Abl interactor 2, dysbindin, X-linked inhibitor of apoptosis (XIAP), p73 transcription factor, among others [ ]. It plays important roles in neuronal differentiation of neural progenitor cells, as well as in controlling cell fate in skeletal muscle progenitor cells [, ]. It reduces PI3K-Akt-FoxO signalling in muscle atrophy by promoting plakoglobin-PI3K dissociation. It also functions as a pluripotency-reprogramming roadblock that facilitates cellular transition towards differentiation via modulating the levels of Oct4 and cMyc [].Moreover, TRIM32 is an intrinsic influenza A virus (IAV) restriction factor which senses and targets the polymerase basic protein 1 (PB1) for ubiquitination and protein degradation [ , ]. It also plays a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo, binding specifically to the activation domain of HIV-1 Tat []; it and can also interact with the HIV-2 and EIAV Tat proteins. TRIM32 also regulates myoblast proliferation by controlling turnover of NDRG2 (N-myc downstream-regulated gene) [ ] and it negatively regulates tumour suppressor p53 to promote tumorigenesis []. It also facilitates degradation of MYCN on spindle poles and induces asymmetric cell division in human neuroblastoma cells. In addition, TRIM32 plays important roles in regulation of hyperactivities and positively regulates the development of anxiety and depression disorders induced by chronic stress []. It also plays a role in regeneration by affecting satellite cell cycle progression via modulation of the SUMO ligase PIASy (PIAS4). Defects in TRIM32 lead to limb-girdle muscular dystrophy type 2H (LGMD2H), sarcotubular myopathies (STM) and Bardet-Biedl syndrome []. TRIM32 belongs to the C-VII subclass of TRIM (tripartite motif)-NHL family that is defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a RING finger, Bbox1, and a coiled coil domain, as well as a NHL (named after proteins NCL-1, HT2A and Lin-41 that contain repeats folded into a six-bladed β-propeller) repeat domain positioned C-terminal to the RBCC domain.This entry represents the type 1 B-box (Bbox1) zinc finger, which is characterised by a C6H2 zinc-binding consensus motif.
Short Name	TRIM32_Bbox1_Znf