Protein Domain : TIAR, RNA recognition motif 3 IPR034496

Type	Domain
Description	This entry represents the RNA recognition motif 3 (RRM3) of TIA-1 and nucleolysin TIAR (TIA-1-related protein), proteins that share high sequence similarity.TIA-1 is the 40kDa isoform of T-cell-restricted intracellular antigen-1 (TIA-1, also known as Cytotoxic granule associated RNA binding protein TIA1), a cytotoxic granule-associated RNA-binding protein mainly found in the granules of cytotoxic lymphocytes [ , ]. TIA-1 regulate alternative pre-mRNA splicing by promoting the use of suboptimal 5' splice sites followed by uridine-rich intronic enhancer sequences. It can be phosphorylated by a serine/threonine kinase that is activated during Fas-mediated apoptosis, and functions as the granule component responsible for inducing apoptosis in cytolytic lymphocyte (CTL) targets [].TIAR is a cytotoxic granule-associated RNA-binding protein that shows high sequence similarity with TIA-1 [ ]. TIAR plays a critical role in transcriptional and posttranscriptional regulation of gene expression []. It binds to target mRNA and DNA via its RNA recognition motif (RRM) domains and is involved in both splicing regulation and translational repression via the formation of stress granules []. TIAR is composed of three N-terminal highly homologous RNA recognition motifs (RRMs) and a glutamine-rich C-terminal auxiliary domain containing a lysosome-targeting motif. Its RRMs are involved in binding to U-rich RNA, but with unequal contributions. RRM2 of TIAR is the major RNA- and DNA-binding domain [].
Short Name	TIAR_RRM3