Protein Domain : SF3B4, RNA recognition motif 2 IPR034159

Type	Domain
Description	This entry represents the RNA recognition motif 2 (RRM2) of SF3B4, also termed pre-mRNA-splicing factor SF3b 49kDa (SF3b50), or spliceosome-associated protein 49 (SAP 49). SF3B4 is a component of the multiprotein complex splicing factor 3b (SF3B), an integral part of the U2 small nuclear ribonucleoprotein (snRNP) and the U11/U12 di-snRNP. SF3B is essential for the accurate excision of introns from pre-messenger RNA, and is involved in the recognition of the pre-mRNA's branch site within the major and minor spliceosomes [ ]. SF3B4 functions to tether U2 snRNP with pre-mRNA at the branch site during spliceosome assembly []. It is an evolutionarily highly conserved protein with orthologues across diverse species.SF3B4 contains two closely adjacent N-terminal RNA recognition motifs (RRMs). It binds directly to pre-mRNA and also interacts directly and highly specifically with another SF3B subunit called SAP 145 [ ].Mutations in the SF3B4 gene cause Nager syndrome, a form of acrofacial dysostosis which affects the development of the face, hands, and arms [ ]. This entry also includes the orthologue from Schizosaccharomyces pombe Spliceosome-associated protein 49.
Short Name	SF3B4_RRM2