Protein Domain : Calponin repeat IPR000557

Type	Repeat
Description	Calponin [ , ] is a thin filament-associated protein that is implicated in the regulationand modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin MgATPase activity. Calponin is abasic protein of approximately 34 Kd. Multiple isoforms are found in smooth muscles. Calponin contains three repeats of a well conserved 26 amino acid domain. Such a domain is also found in vertebrate smooth muscle protein(SM22 or transgelin), and a number of other proteins whose physiological role is not yet established, including Drosophila synchronous flight muscle protein SM20, Caenorhabditis elegans unc-87 protein [], rat neuronal protein NP25[ ], and an Onchocerca volvulus antigen [].
Short Name	Calponin_repeat