Protein Domain : Knottin, scorpion toxin-like superfamily IPR036574

Type	Homologous_superfamily
Description	Knottins are small proteins characterised by a cystine-knot [ ]. They constitute a large family of structurally related peptides with diverse biological functions, including inhibitors, anti-microbial peptides and toxins []. Their structure is composed of a disulfide-bound fold and contains β-hairpin with two adjacent disulfides.The scorpion toxin-like domain is found in a subgroup of metazoan knottins mainly from the arthropoda, which include the antibacterial defensins [ ] and the scorpion alpha-neurotoxins [, ]. The plant sequences include members of the gamma-thionin family, which are plant defensins that have no antifungal activity. Other members are insect alpha-amylase inhibitors, cysteine-rich antifungal proteins and proteins annotated as proteinase inhibitors; those that are characterised belong to MEROPS inhibitor family I18, clan I.
Short Name	Scorpion_toxin-like_sf