LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their N-terminal regulatory domain [ , ]. Atypical protein kinases C (aPKCs) have a PB1 and an atypical C1 domain, which only accepts phosphatidylserine [].In mammals there are two aPKC isoforms, zeta and iota/lambda (iota is the human orthologue and lambda the mouse orthologue) [ ]. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation [, ]. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes [, ].PKC-iota is directly implicated in carcinogenesis [ ]. It is critical to oncogenic signalling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumour-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumour cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers []. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions []. |
| Short Name | aPKC_iota |
