Protein Domain : Growth factor receptor-bound protein 7, SH2 domain IPR035032

Type	Domain
Description	Grb7 (growth factor receptor bound protein 7) is an adapter protein mediating signal transduction from multiple cell surface receptors to diverse downstream pathways [ , , ]. It contains a Ras-associating (RA) domain, a pleckstrin-homology (PH) domain, a family-specific BPS (between PH and SH2) region and a C-terminal SH2 domain [, ]. This entry represents the C-terminal SH2 domain of Grb7. It is responsible for the binding of this protein to the epidermal growth factor receptor (EGFR, erbB1) via the SH2 domain [ ].
Short Name	Grb7_SH2