Protein Domain : SOCS4, SH2 domain IPR035864

Type  Domain
Description  SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS4 (Suppressor of cytokine signalling 4) is the substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins [ ]. SOCS4 and SOCS5 regulate epidermal growth factor receptor signaling [].This entry represents the SH3 domain of SOCS4.
Short Name  SOCS4_SH2

0 Child Features

0 Gene Families

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0 Ontology Annotations

1 Parent Features

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