Protein Domain : Small ubiquitin-related modifier 1, Ubl domain IPR046332

Type	Domain
Description	This entry represents the ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO1) and similar proteins from animals. SUMO1 is a binding partner of the RAD51/52 nucleoprotein filament proteins, which mediate DNA strand exchange [ , , ]. Its conjugation to cellular proteins has been implicated in multiple important cellular processes, such as nuclear transport, cell cycle control, oncogenesis, inflammation, and the response to virus infection [, , , ]. SUMO resembles ubiquitin (Ub) in structure, binding to other proteins and the mechanism of ligation. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Ubiquitination is comprised of a cascade of E1, E2 and E3 enzymes that results in a covalent bond between the C terminus of Ub and the ε-amino group of a substrate lysine. SUMOs, like Ub, are covalently conjugated to lysine residues in a wide variety of target proteins in eukaryotic cells and regulate numerous cellular processes, such as transcription, epigenetic gene control, genomic instability, and protein degradation [, , ].
Short Name	SUMO1_Ubl