Protein Domain : Abl-interactor, homeo-domain homologous domain IPR012849

Type  Domain
Description  The region is found towards the N terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases [ ]. More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins []. Other homeo-domain proteins have been implicated in specifying positional information during embryonic development, and in the regulation of the expression of cell-type specific genes []. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved in cytoskeletal reorganisation, but their precise role remains unclear [].
Short Name  Abl-interactor_HHR_dom

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