Protein Domain : Growth arrest and DNA damage-inducible protein GADD45 IPR024824

Type  Family
Description  The growth arrest and DNA damage GADD45 proteins, which include GADD45A, GADD45B , and GADD45G, are implicated as stress sensors that modulate the response of mammalian cells to genotoxic/physiological stress, and modulate tumor formation [ , , ]. GADD45 proteins interact with a number of other proteins implicated in stress responses, including PCNA, p21, Cdc2/CyclinB1, MEKK4, and p38 kinase. GADD45 stimulates DNA excision repair in vitro and inhibits the entry of cells into S phase during the cell cycle.
Short Name  GADD45

0 Child Features

0 Gene Families

0 Genes

2 Ontology Annotations

0 Parent Features

0 Publications

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