Protein Domain : PET testin IPR033724

Type  Domain
Description  Testin contains a PET domain at the N terminus and three C-terminal LIM domains [ ]. It is a cytoskeleton associated focal adhesion protein that localizes along actin stress fibres, at cell-cell contact areas, and at focal adhesion plaques [, ]. Testin interacts with a variety of cytoskeletal proteins, including zyxin, mena, VASP, talin, and actin and is involved in cell motility and adhesion events. Knockout mice experiments have revealed a tumour repressor function. [, ].The entry represents the testin PET domain. It is a protein-protein interaction domain and PET containing proteins serve as adaptors or scaffolds to support the assembly of multimeric protein complexes.
Short Name  PET_testin

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