Protein Domain : LppX/LprAFG lipoprotein family IPR009830

Type	Family
Description	This entry consists of several lipoproteins mainly from Mycobacterium species, collectively known as the LppX/LprAFG family. Proteins in this entry include:LprG ( ) from Mycobacterium tuberculosis: an immunogenic 27kDa membrane-associated lipoprotein [ ]. Expression of the LprG protein is essential for the growth of M. tuberculosis in immunocompetent mice []. Purification of LprG showed that it inhibits MHC-II antigen processing in primary human macrophages, providing a mechanism to avoid the host MHC-II-restricted CD4+ T cell response which is considered essential for control of M. tuberculosis infection []. LppX: a lipoprotein required for the translocation of complex lipids to the outer membrane of Mycobacterium tuberculosis. Its structure consists of a U-shaped β-half-barrel with a large hydrophobic cavity [ ]. LprF: a membrane lipoprotein involved in the kdp signal transduction pathway, thought to be the primary response to osmotic stress [ ].lprA: a lipoprotein agonist of TLR2 that regulates innate immunity and APC function [ ].
Short Name	LppX/LprAFG